SIANOKOBALAMINA (HUAWITAMINA B12)
Āhua me ngā Āhuatanga
He paura karaihe whero, he paura karaihe rānei tēnei hua, kāore he kakara, kāore he reka, ā, he kaha te whakapūmau i te makuku. He paku wairewa ki te wai, ki te etanoru rānei, kāore e wairewa ki te chloroform, ki te ether rānei. He ātete ki te wera, engari kāore e whai hua ina pāngia e ngā matū waikura, whakaiti rānei, ngā tote konganuku taumaha me ngā waikawa kaha me ngā kawakore kaha.
Hanganga Matū
He matū rite tonu te Huaora B12 kei roto ngā iona cobalt. Ko tōna hanganga pokapū he mowhiti corrin papatahi e hangaia ana e ngā pyrrole e whā e hono ana. E toru ngā wāhanga o ngā ngota o te Huaora B12: he mowhiti gourin kua honoa e ngā ngota N e whā me ngā iona cobalt pokapū; 5,6-dimethylbenzimidazole e hono ana ki ngā ngota N-7 me ngā iona cobalt hei ngota huaora B 12 o ngā ligands taumata-iti. Hei tāpiri, ka honoa hoki te DMBI ki te aminopropanol mā roto i ngā rōpū phosphate, ā, ka honoa te aminopropanol ki te mekameka taha waikawa propionic i runga i te pyrrole D; rōpū adenosyl, rōpū methyl rānei. Ka honoa ki ngā iona cobalt hei hanga i te ligand o runga o ngā ngota huaora B12.
Te Mahi ā-tinana
Ka taea e te korenga o te huaora B12 te arahi ki te neuritis peripheral. Ko ngā whakaaturanga tōmua o te korenga o te huaora B12 i roto i ngā tamariki ko te āhua rerekē, te puhoi o te whakaaturanga, te puhoi o te tauhohenga, ā, i te mutunga ka arahi ki te anemia. Ka whakatairanga i te whanaketanga me te pakeketanga o ngā toto whero. Ka hurihia te Methylpropandiyl coenzyme A ki te succinoyl coenzyme A, ā, ka whai wāhi ki te huringa waikawa tricarboxylic, e hono ana te succinyl coenzyme A ki te hanganga o te heme. Ka whai wāhi hoki te Huaora B12 ki te hanganga o te waikawa deoxynucleic (DNA), te pākia o te ngako, te warowaihā me te pūmua, ā, ka whakanui ake i te hanganga o ngā waikawa nucleic me ngā pūmua.
